Caithness Biotechnologies: Natural product libraries for drug discovery Harnessing Nature for drug discovery
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1) Advantages
2) Novelty
3) Rationale
4) Intellectual property
5) Unique molecules
6) Hit-rate
7) Diversity
8) Resupply
9) Unextracted herbs
10) Extraction
11) Ethnic data
12) Screening
13) Shelf-life
14) Kit sizes
15) Separation
16) Human studies
17) Pre-fractionation
18) 'Frequent hitters'


Natural product libraries for drug discovery


Frequently asked questions

06) What ‘hit-rate’ can I expect from the library?

The hit rates of screening campaigns vary considerably depending on the target, the variability of the bioassay and the signal to background ratio of the reporter used.

However, as a general rule, the screening of natural product libraries tends to offer a far higher hit rate than synthetic chemical libraries.

For example, screens of ~7,000 natural product-derived polyketide metabolites have yielded 20 commericalised drugs (an overall hit rate of 0.3%, all the way through to approval and commercialisation) [1].

By contrast, the hit rate of HTS of synthetic libraries can be lower than 0.001%. [1]

It is impossible to estimate how many hits you will generate using your own assay to screen the Phytotitre library.

However, hit rates of 0.1% to 1% are not uncommon for cell- or protein-based screening assays of natural product extract libraries after counterscreen triage.

[1] Weissman KJ, Leadlay PF. Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol 3:925-36 (2005)

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Natural product libraries for drug discovery


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