Caithness Biotechnologies: Natural product libraries for drug discovery Harnessing Nature for drug discovery
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1) Advantages
2) Novelty
3) Rationale
4) Intellectual property
5) Unique molecules
6) Hit-rate
7) Diversity
8) Resupply
9) Unextracted herbs
10) Extraction
11) Ethnic data
12) Screening
13) Shelf-life
14) Kit sizes
15) Separation
16) Human studies
17) Pre-fractionation
18) 'Frequent hitters'


Natural Product libraries for drug discovery


Frequently asked questions

17) To what extent has the Phytotitre library been pre-fractionated?

A balance needs to be struck between the number of fractions of each extract used to prepare a natural product library prior to screening, and the costs of the subsequent screening efforts.

Pre-fractionation can reduce interference between compounds within samples, so increasing the hit-rate, and simplifies subsequent activity-guided separation.

However, increasing the number of pre-fractions also increases the number of plates that must be screened, and accordingly the labour, time and cost of the screening component of the work.

Phytotitre provides two pre-fractions per sample, one polar and one non-polar, since this balances optimum library size with ease of subsequent separation techniques.

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Natural product libraries for drug discovery


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