Harnessing Nature for drug discovery |
FAQ 1) Advantages
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Frequently asked questions 17) To what extent has the Phytotitre library been pre-fractionated? A balance needs to be struck between the number of fractions of each extract used to prepare a natural product library prior to screening, and the costs of the subsequent screening efforts. Pre-fractionation can reduce interference between compounds within samples, so increasing the hit-rate, and simplifies subsequent activity-guided separation. However, increasing the number of pre-fractions also increases the number of plates that must be screened, and accordingly the labour, time and cost of the screening component of the work. Phytotitre provides two pre-fractions per sample, one polar and one non-polar, since this balances optimum library size with ease of subsequent separation techniques.
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