High quality reagents for innate immunity research, vaccine development and drug discovery

		Further resources relevant to the Phytotitre natural extract library Phytotitre FAQ Please click here to view the comprehensive list of frequently asked questions relating to the Phytotitre collection. List of plant species included in the Phytotitre library Please click here to read more about the plant species included in the Phytotitre library. Why choose to screen a natural product library? For an in depth discussion of the relative merits and disadvantages of screening natural product and synthetic compound libraries, please click here. Refinements specific to the Phytotitre collection Natural product screening has several pros and cons in comparison to synthetic compound screening. Discussion of these points, including the specific ways in which the Phytotitre natural product library has been optimised to address these issues while maximising ease of use and potential for discovery of active compounds, is available here. Drug discovery is evolving Please click here to read how more focussed libraries are taking the lead in modern drug discovery. Potential for novelty Please click here to read more on the potential for discovery of novel compounds and IP generation using natural product screening. Free data available to download Sample data from our own basic screens of the Phytotitre library are provided free of charge for research, student project and educational purposes. Please click here to view a current list of available screening data. Basic methods for library screening and compound identification If you are new to natural product library screening, or the separation of active compounds from natural extracts, please click here to view a selection of sample methods and online resources which may be of assistance to your research programme. Natural product news Please click here to view recent news in the field of natural product screening. Publications using this library Please click here to view a list of publications using our natural product libraries. Links to online natural product databases and other support OMICtools offers a useful list of links to natural product databases. http://omictools.com/natural-products-category The Dictionary of Natural Products Online includes information on all compounds contained in the Dictionary of Natural Products. http://dnp.chemnetbase.com/intro/ Chem-TCM is a digital database of individual phytochemicals of plants used in the traditional Chinese herbal medicine. http://www.chemtcm.com/ Super Natural II is a natural product database with information on 325,508 compounds. http://bioinf-applied.charite.de/supernatural_new/index.php The Metlin database for metabolite identification offers a very simple m/z based search option. https://metlin.scripps.edu/metabo_search_alt2.php Universal Natural Product Database collates information on 197,201 3D structures. http://pkuxxj.pku.edu.cn/UNPD/ This online video, presented by Drs Jim Wells and Michelle Arkin of UCSF, introduces the major concepts of library screening, including coverage of the ‘Z-prime’ calculation. https://www.youtube.com/watch?v=KQKppAAR3ME This article provides a good example of the steps involved in compound separation by HPLC, and subsequent structural identification: Shibata T. et al J Biol Chem 289:32757-72 (2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239626/

 

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